Cytogenetic analysis is one of the basic contents of MICM typing of hematologic malignancies recommended by WHO. Many specific chromosomal aberrations are associated with specific hematologic subtypes, and therefore they become important indicators of the diagnostic typing of hematologic malignancies. The chromosomal karyotype has an independent prognostic value in the diagnosis of hematologic malignancies.
Florescence in Situ Hybridization (FISH) is a detection technique of in situ hybridization of samples using non-radioactive fluorescent signals. The technique is easy to operate for quick detection, with high repeatability and specificity, and it can complement with the karyotype analysis.